(2016) Transient Global Amnesia Deteriorates the Network Efficiency of the Theta Band. This effect might be related to the desynchronization between the anterior and posterior brain areas.Ĭitation: Park YH, Kim J-Y, Yi S, Lim J-S, Jang J-W, Im C-H, et al. Our results indicate that TGA deteriorates the network efficiency of the theta frequency band. The nCC of the theta band with a mean degree of 5.5 significantly decreased during the acute stage ( P < 0.05). During the acute stage, the lost edges for these networks were mostly found between the anterior (frontal and anterior temporal) and posterior (parieto-occipital and posterior temporal) brain regions, whereas newly developed edges were primarily found between the left and right frontotemporal regions. During the acute stage of TGA, the nCPL of the theta band networks with mean degrees of 8, 8.5, 9 and 9.5 significantly increased ( P < 0.05). For networks where the nCPL or nCC differed significantly between the two stages, we also evaluated changes in the connections of the brain networks. We investigated whether the normalized characteristic path length (nCPL) and normalized clustering coefficients (nCC) differed significantly between the acute and resolved stages of TGA at each frequency band using the Wilcoxon signed-rank test. Characteristic path lengths and clustering coefficients of functional networks constructed using phase-locking values were computed and normalized as a function of the degree in the delta, theta, alpha, beta 1, beta 2 and gamma frequency bands of the EEG. The EEG data were obtained twice, once during the acute stage ( 2 months after symptom onset) of TGA. Graph theoretical analysis was applied to resting-state EEG data collected from 21 patients with TGA. We tested the hypothesis that network efficiency, meaning the efficiency of information exchange over a network, is impaired during the acute stage of TGA. Accessed June 27, 2022.Acute perturbation of the hippocampus, one of the connector hubs in the brain, is a key step in the pathophysiological cascade of transient global amnesia (TGA). Genetic and Rare Diseases Information Center. In: Bradley and Daroff's Neurology in Clinical Practice. Transient global amnesia: Current perspectives. In: Adams & Victor's Principles of Neurology. Dementia, the amnesic syndrome, and the neurology of intelligence and memory. No signs of seizures during the period of amnesiaĪnother common sign of transient global amnesia due to the inability to create new memories includes repetitive questioning, usually of the same question - for example, "What am I doing here?" or "How did we get here?".Symptoms lasting no more than 24 hours and generally shorter.More symptoms and history that may help diagnose transient global amnesia: No signs of damage to a particular area of the brain, such as being unable to move an arm or leg, movements you can't control, or problems understanding words.Normal cognition, such as the ability to recognize and name familiar objects and follow simple directions.Being awake and alert and knowing who you are, despite memory loss.
Sudden onset of confusion that includes memory loss, seen by a witness.You must have these signs and symptoms to be diagnosed with transient global amnesia: Once that symptom is confirmed, ruling out other possible causes of amnesia is important. The main symptom of transient global amnesia is being unable to create new memories and remember the recent past. Transient global amnesia isn't serious, but it can still be frightening. During recovery, you may begin to remember events and circumstances. Episodes of transient global amnesia always get better slowly over a few hours. With transient global amnesia, you do remember who you are, and you recognize the people you know well. The condition most often affects people in middle or older age. You may also draw a blank when asked to remember things that happened a day, a month or even a year ago.
You may keep repeating the same questions because you don't remember the answers you've just been given. You may not remember anything about what's happening right now. You can't remember where you are or how you got there. This confused state isn't caused by a more common neurological condition, such as epilepsy or stroke.ĭuring an episode of transient global amnesia, a person is unable to create new memory, so the memory of recent events disappears. Transient global amnesia is an episode of confusion that comes on suddenly in a person who is otherwise alert.
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